The tenure difference is real and it's the main operating advantage. Single-family tenants tend to stay longer than apartment tenants, often several years rather than one or two, because families with kids in a school district move less. Longer tenure means fewer turns, and the turn is the expensive event, so your annual expense line can come out better than your worse-per-unit economics would suggest.
What you lose is exactly what you listed. One vacancy is 100 percent of the income on that property, not 50 percent. That changes how much reserve you need per property, and it's why a single house wants six months of full carrying cost behind it rather than the thinner reserve a duplex can survive on.
On the yard, budget it as a real line. A basic mow-and-trim contract commonly runs $30 to $60 a visit in season, so a few hundred to a thousand dollars a year depending on lot size and climate. You can write the lease to make yard care the tenant's responsibility, and many single-family leases do, but enforcement is uneven and a neglected yard is a code citation in some municipalities and a slow decline in the property in all of them. A lot of owners keep the mowing in-house and price it into rent.
The number that genuinely changes on you is capital reserve. Your duplex spread the roof across two rents. On a house, the roof, the HVAC, the water heater, and the exterior paint all sit against one rent stream. Set that reserve in dollars off replacement cost rather than as a percentage of rent, because a percentage of rent will leave you under-reserved on a lower-rent house without your noticing.
One more thing to check before you're under contract: whether the house sits in an HOA. HOAs can cap rentals, impose a waiting period after purchase, or require tenant approval, and those rules vary by association and by state. Read the covenants, not the listing.